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Association of a missense mutation in the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) with superovulation traits in Chinese Holstein heifers

Yong Yu, Yunwei Pang, Haichao Zhao, Xiaoling Xu, Zhonghong Wu, Lei An and Jianhui Tian*

Author Affiliations

Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, PR China

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Journal of Animal Science and Biotechnology 2012, 3:35  doi:10.1186/2049-1891-3-35

Published: 9 November 2012



Upon binding luteinizing hormone in the ovary, the luteinizing hormone/choriogonadotropin receptor (LHCGR) is necessary for follicular maturation and ovulation, as well as luteal function. We detected mutations in the LHCGR gene and evaluated their association with superovulation.


Using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and DNA sequencing, we examined polymorphisms in LHCGR and the genotypes associated with superovulation traits in 127 Chinese Holstein heifers.


A G/T polymorphism (ss52050737) in exon 11 was significantly associated with the total number of ova and the number of transferable embryos.


LHCGR may be a new predictor for superovulation in Chinese Holstein heifers.

Chinese Holstein heifer; LHCGR; SNP; Superovulation